Dismiss Notice
Welcome! Please read this announcement regarding the new Forums: Click Here"

Article about Androgenetic Alopecia and stuff against it

Discussion in 'New Research, Studies, and Discoveries' started by GoodYear, Aug 26, 2008.

  1. GoodYear

    GoodYear Guest


    I found in my search for TNF alpha inhibitors (that is what I get as a medicin for rheuma) an interesting article about Androgenetic Alopecia, its DHT inhibitors, Aromatase (an enzym that is supposed to convert testosterone into estrogen), a new invention (that is why this article is publiced: relaxin that is supposed to be medicin against Androgenetic Alopecia!

    In the article:
    Relaxin is a small polypeptide member of the protein hormone family, which also includes insulin and insulin like growth factors IGF-1 and IGF-2. Relaxin is expressed during pregnancy.
    The patterns of relaxin and relaxin binding cells indicates that in the
    hair follicles these patterns may act not only directly as mitogen on the
    germinative cells and on the outer root sheath, but also indirectly on the
    dermal papilla stimulating the production of growth factors. The binding
    cells of relaxin in the outer root sheath indicate that relaxin may play a
    role in regulating terminal differentiation.

    There is no single hair growth factor. Hair growth is an interaction
    between several different cytokines, however, two cytokines stand out from
    the rest in terms of importance; these are IGF-1 and TGF-BETA. IGF-1
    maintains hair follicles in the anagen phase. The follicles enter catagen
    if IGF-1 is absent. IGF-1 and IGF-1-R gene expression declines. TGF-BETA
    triggers the catagen phase. It is a potent inhibitor of hair growth in
    vitro. Relaxin increases IGF-1 and decreases TGF-BETA therefore it has the
    desired effect on hair growth and prevention of hair loss.
    From relevant histology we learn that those afflicted with androgenetic
    alopecia demonstrate: (1) an increase of 5 alpha reductase activity: (2)
    an increase in the production of dihydrotestosterone; (3) lower aromatase
    activity: and (4) reduced production of estradiol. Those afflicted with
    androgenetic alopecia also demonstrate inflammation, follicular streamers,
    dermal and perifollicular fibrosis, atrophy and sclerosis with net results
    of miniturization of the hair follicle. Moreover, androgenetic alopecia is
    characterized by a progressive shortening of the average duration of the
    anagen phase with net results of terminal hair transformation into vellus
    hair before complete disappearance.

    Not that we have the lotions they express, it gives some insight that Androgenetic Alopecia is not treated by DHT inhibitors only. It is quite interesting. Also good explanation of Androgenetic Alopecia.

    http://www.patentstorm.us/patents/60750 ... ption.html
  2. SabrinaLouise

    SabrinaLouise Senior Member

    Mar 16, 2009
    Likes Received:
    Dislikes Received:
    Thanks for posting this GoodYear :)
  3. kimm

    kimm Guest

    I found the part about relaxin really interesting!

    This could partially account for increased hair thickness during pregnancy!
  4. curlylocks

    curlylocks Guest

    Relaxin is the hormone that allows your bones to "relax" during pregnancy to allow the baby to pass through the pelvic area. I had too much relaxin during my last pregnancy (great hair, though) which caused my knee to continually give out on me even after the baby was born. I had to wear a brace and go through physical therapy to cure this.
  5. I just read a bunch about Relaxin -- seems almost too good to be true. It's the "youth" hormone -- makes skin, hair etc look more youthful AND it decreases insulin resistance (for those pcosers) also you can get it over the counter as a supplement called "vitalaxin"

    Everything I read said it's safe -- but it was mostly from one source -- the inventor. I know women with fibromyalgia have been taking it w/ pretty good results. Not sure if anyone has taken it just for hairloss. I'd be willing to give it a go in some kind of a topical application before ingesting it -- since I don't like to mess w/ hormones.
  6. so-lost

    so-lost Guest

    Really interesting...if being used for fibromyalgia, can we assume it doesn't have major adverse effects? I'm going to start a thread to see if anyone's using.
  7. vaso

    vaso Established Member

    Sep 4, 2008
    Likes Received:
    Dislikes Received:
    Very interesting article and it definitely puts the connection between pregnancy and great hair - i do remeber my body been more relaxed during my pregenancies and i would often get stuck trying to move around from sitting positions to upright positions. Im not sure that i would want that all the time.

    So basically it puts the hairs in anagen phase longer rather than going into catagen phase in a sense skipping a hair cycle. But how do we get to reverse miniturisation??? that's what we really need.
  8. CarliGali

    CarliGali Guest

    Super interesting. ANYONE have tried it?
  9. erin

    erin Guest

    well, this was an old threat. But maybe they can make a topical version of this substance and use it to treat Androgenetic Alopecia. Then it wouldn't have other side effects.
  10. GoodYear

    GoodYear Guest

    Thanks for open this thread again. I never took action into this, but I am going to explore if I can find some more information about this.
  11. April_moon

    April_moon Member

    Sep 24, 2016
    Likes Received:
    Dislikes Received:

    - - - Updated - - -

    right. I hate side effects, if I see two I can't do it... but its neat to learn about all these different hormones and how they tie in with Androgenetic Alopecia

Share This Page