Okay, y'all. Buckle up for a wild ride. I am 29F with a strong family history of thinning hair, both women and men. My brothers went bald between 18-21. My mom has thin hair which she cuts and styles very cleverly and she looks beautiful, but I want to be able to have long hair for as long as possible and what if my hair loss is actually more aggressive than hers? So I'm treating mine now. When I was 17 I experienced by first big hormonal shed, which coincided with my first use and discontinuation of hormonal birth control. I experienced big sheds throughout my twenties while stopping, starting, or changing birth control (I used Ortho Tri Cyclen for the longest, and had no perceptible side effects), or when I had my son three years ago. My hair got thinner and thinner but still looked fine so I didn't treat it. After I had my son, I also developed severe postpartum depression/anxiety and went on Zoloft (I used the generic, sertraline). My hair grew in thicker, after my postpartum shed, than it had been since I was 20 or so. Thicker than it had been during pregnancy, for sure. I had clear skin, and lost a bit of weight (I'm short, and I've weighed about 110 lbs my whole adult life. I weighed 106 or so while on sertraline). I thought that maybe all these positive changes were just what my body was like while not on the Pill. I discontinued sertraline after 8 months. Over the two years since then, I have slowly gained weight (now 116 lbs), my periods have become irregular (up to 45 days), and I have had constant heavy shedding (I'd say 200 hairs on average). Iron deficiency was treated but has not improved hair loss. Thyroid within range. Testosterone is normal (right in the middle of the range), DHEAS 235 (which is normal, but is associated with androgen excess symptoms), DHT is very low (turns out DHT isn't as strongly associated with women's hair loss as is testosterone), but estrogen is low and progesterone is 0 when I should be ovulating and it should be high. I kept thinking, "Why in the hell did I seem to do well on Zoloft when there are so many reports of people losing their hair and gaining weight on it?" I kept telling myself it was coincidence. Then, randomly, while nose deep in PubMed, I stumbled upon a few articles reporting that SSRIs increase SHBG, aromatase, and estrogen, and decrease androgens. Holy shit. So now I think it really WAS Zoloft that regrew my hair. In any case, I've tried every single herb and supplement in the universe (I was most recently trying DIY hormone therapy with soy isoflavones, but then got spooked about it leading to hypothyroidism and stopped). I tried PRP, which made things worse FAST. It's time for me to try more powerful drugs. My options are 1) spironolactone, alone or in combination with Ortho-Cyclen (my husband has had a vasectomy so I might be able to use it without, depending on my gyno). I am concerned about weight gain on this as I already gain weight eating much less than I used to, but I'd rather be a bit heavier and have my hair. 2) just go back on Zoloft and see if it does what I suspect it did last time, and stay on it for as long as it does that, and then cross the antiandrogen bridge when I have to. I should mention that I am technically severely depressed (no shit, I would guess everyone on this board is) and it might help me to be on Zoloft anyway. Thoughts? Experiences? Advice? Love Spironolactone? Hate Spironolactone? Spironolactone better with/without birth control pills? Zoloft also made you a gorgeous Godiva? Let me know, friends. As always, love and hugs to all my sisters going through the worst. thing. ever.