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Hypothyroid, Cortisol, Prolactinemia linked to Androgenetic Alopecia

Discussion in 'New Research, Studies, and Discoveries' started by Panicked Rapunzel, Nov 22, 2005.

  1. http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

    1: Hautarzt. 1991 Mar;42(3):168-72. Related Articles, Links


    [Hyperprolactinemia and hypophyseal hypothyroidism as cofactors in hirsutism and androgen-induced alopecia in women]

    [Article in German]

    Schmidt JB, Lindmaier A, Spona J.

    II. Universitats-Hautklinik, Wien.

    A more comprehensive hormonal diagnosis than has previously been performed shows that androgen-dependent diseases of hair growth are due to more varied hormonal disturbances than elevated androgen serum levels alone. In 46 female patients with androgenic hair loss and 27 patients with hirsutism, the levels of the androgens testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulphate and 17-hydroxyprogesterone and of sex hormone-binding globulin, cortisol, oestradiol and the hypophyseal hormones follicle-stimulating hormone and luteinizing hormone were determined and compared with the hormone levels of 27 female patients without endocrine disorders. Of the androgens, only androstenedione showed a slightly significant elevation in hirsutism. Cortisol was elevated significantly in androgenic hair loss, and with a low degree of significance in hirsutism. In view of the complex hormonal interactions of thyroxin, prolactin and androgens and thyroid hormones the thyrotropin-releasing hormone (TRH)-stimulation test was performed in 38 female patients with androgenic hair loss and 27 with hirsutism, and the results were compared with those recorded in 45 female control persons. The test is based on feedback mechanisms between hypothalamic TRH and hypophyseal TSH and prolactin and peripheral thyroid hormones. Baseline concentrations of TSH prior to stimulation were significantly elevated in hirsutism, while in androgenic hair loss both baseline and stimulated TSH levels were significantly elevated; thus, hypothyroidism is a significant finding in both clinical pictures. In the case of prolactin, both baseline and stimulated levels were highly significantly elevated in hirsutism, while in androgenic hair loss the stimulated levels were significantly elevated.(ABSTRACT TRUNCATED AT 250 WORDS)

    PMID: 1905280 [PubMed - indexed for MEDLINE]
     
  2. ncny

    ncny Guest

    Here's another one, sort of similar in subject:

    http://www.keratin.com/ao/ao009ref003.shtml

    Schmidt JB. Hormonal basis of male and female androgenic alopecia: clinical relevance. Skin Pharmacol 1994;7(1-2):61-6
     
  3. ncny

    ncny Guest

    Oops...sorry! I think it's the same study, different wording.

    I think this could be roughly interpreted to mean that they found a surprising amount of correlation between women with Androgenetic Alopecia hair loss and hypothyroidism, even in women without thyroid conditions.

    Woman with Androgenetic Alopecia hair loss seem to have the following hormone profile:

    high androstenedione (an androgen)
    high TSH (indicates a hypothryoid condition)
    high cortisol (stress hormone)
    high prolactin (which can stimulate androgens, cause problems with menstruation)
     
  4. leia1993

    leia1993 Guest

    Thanks for posting this. I have very high cortisol but no other abnormal hormone values... Hmmmm...
     
    Georgina likes this.
  5. My endo's nurse called me today. They were reviewing my labs and it seems that my cortisol is low.

    They think this is important enough for me to come in in the morning without an appt for some kind of adrenal gland stimulation test.

    I looked it up , and of course adrenal insuffiency (low cortisol) is linked to hair loss.

    The Hepatitis B vaccine is also linked to hair loss. Of course, I had to have the Hep B vaccination series twice, with a booster, because I would not seroconvert as immune.
    (I work with dialysis pts, which puts me at high risk to be exposed to Hep B).

    I'm starting to think that everything in the world can cause hair loss.
     
  6. redclaire

    redclaire Guest

    Thanks Rapunzel. It sort of goes with what I've been thinking. My chin hair, and oily skin all started about the same time I was hit with fatigue and vertigo.

    The I upped my own dosage five weeks ago and till this week I had about a good three weeks of not oily skin, no break outs, etc. Well, with the cold weather comes a slow down in the thyroid and bamn! I'm hit with vertigo ( major today) and fatigue ( first time today in three weeks) and oily skin again.

    Though, they call our hair loss Androgenetic Alopecia... I'm suspecting that's not necessarily the case at all. I suspect that getting our TSH levels under control is the first step in getting the other hormone levels under control ( granted as we age those may need a little more help than simply TSH). I dare say that thyroid patients and women with other hormones out of wack are most likely going through CTE more than anything else and because doctors refuse to treat us we keep sliding further and further into the hair loss nightmare.
     
  7. redclaire

    redclaire Guest

    ugh, also add to this weeks return of the thyroid issues.... eczema on the backof my hand!!!!

    I first started suffering with it when I was bussing tables back in my early 20's ( probably due to the harsh chemicals) and got it under control before my daughter was born. Well, just before my hair shed I'd had a fresh outbreak of it on the back of my hand. Sort of right when all the poop hit the fan... here it is again.... now I totally believe what I'd read bout cold weather and TSH levels. ( It just started to get really cold here last week)
     
  8. dorothy

    dorothy Guest

    I think for many people "Androgenetic Alopecia" means a deficient state where the thyroid and the adrenals, and the immune system are all weak. I know for certain that something more than hair loss is going on with me, especially with my fatigue.
    Dorothy
     
  9. redclaire

    redclaire Guest

    Yup. I guess I just look at Androgenetic Alopecia as a doctor's way of saying " Too bad so sad go get some Rogaine"
     
  10. I think you're right. Dr. Redmond does not like the term Androgenetic Alopecia, he calls it HA- hormonal alopecia.

    Sounds more accurate to me, since cortisol, tsh, etc are all hormones.
     
  11. redclaire

    redclaire Guest

    Ahhhh, I like HA much better. There's something there that suggests a goal, something to work against.
     
  12. teester

    teester Guest

    At my recent derm appt I requested the remaining labs I need to see what is going on and I wanted to add cortisol level and she said it has nothing to do with hairloss. Am I the only person to come into her office for hairloss...i think not. I know if I was a derm I would research and review my area of responsibility. So I got home and looked over my lab rec. She reordered some tests I already had so I crossed them off and checked off everything I want. I will deal with the reprimand later.

    I am a little confused PR says low cortisol causes hairloss and ncny says high cortisol. Hep B is a manditory immunization....do you think that means all the little kiddo's walking around are going to suffer from hairloss?
     
  13. redclaire

    redclaire Guest

    I think any hormone that is too far off the mark, whether it is low or it is high can cause hair loss. And I wouldn't be surprised if there isn't a drastic rise in hair loss in the next generation due to some of these immunizations.
     
  14. kookla

    kookla Guest

    Well, my thought is that Androgenetic Alopecia should not be an automatic sentence with perimenopause/menopause. Why should doctors throw out Androgenetic Alopecia as an automatic diagnosis, even with no genetic history of hair loss in one's family? It really annoys me, it feels like no one is listening. All the clues are there but these doctors can't put the puzzle together.
     
  15. Cortisol too high or too low can cause hair loss. Hep B vaccines trigger an immune response in some people, which can lead to hair loss.

    Hep B vaccine is required for kids now?

    In the US?
     
  16. leia1993

    leia1993 Guest

    Other than trying not to "stress", what other steps can a person take to lower their Cortisol? I was checked for physiological problems that could cause high cortisol, including an adrenal tumor, etc... I'm wondering if anyone knows of any "natural" remedies for trying to get Cortisol DOWN... THANKS!!!
     
  17. Yes, cortisol, tsh and others can cause hair loss if they are either too low or too high.

    And...androgens can be in range and still cause hair loss. Studies show that many women (and men) with Androgenetic Alopecia don't have high DHT or testosterone levels, but they do have an increased number of receptors in their hair follicles for these hormones.
     
  18. Hairjunkie

    Hairjunkie Guest

    One question I have asked myself a lot since i suffer from hair loss is "What do these doctors learn in all those years they study?"
    I had at least 4 dermatologists diagnose me with Androgenetic Alopecia after only a very superficial look at my scalp. The fact that my father became bold at a very young age was apparently enough to diagnose me. OK, one of them bothered to do a bloodtest which showed that my zinc level was too low.

    But I have recently seen this general practicioner who is specialised in digestive problems, and he asked me to do some specific tests because he said I was borderline anemic. My hematocrite is very low and so is my hemoglobine. I have started to ask for copies of blood analysis because I sometimes think I know it better than the doctors and I have noticed that my hematocrite level is very low since a couple of years. How is it possible that no doctor never saw this before?
    So according to this GP it is no wonder I am losing my hair because I am borderline anemic. Apparently my cortisol is also to low (I have had major stress over the last 3 years) and I have a vitamine D insufficiency. My testosterone was normal but my oestradiol was also low so he has prescribed me isoflavone tablets to wake up the oestradiolreceptors. I have been on BCP for the hair loss, but I have read Dr. Lee's book about premenopause and I never ever want to swallow synthetic hormones.

    I sent a mail to the other Dr. Lee, the one who is selling Minoxidil on the internet. He sent me a kind mail with a lot of explanation and said that my iron levels were too low to have a lot of effect with Minoxidil right now. He advised me to get them as hight as 80.

    So it's kind of amazing how all these different doctors give different interpretations to results of blood analyses.
     
  19. April_moon

    April_moon Member

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    Same. I think Androgenetic Alopecia is purely horomonal and I think all alopecia's are an inside job-- whether you have an auto immune disease or a hormonal one... I think the cure could be found by fixing your insides. I want to try and play with different diets.
     
  20. Lois

    Lois New Member

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    No immunizations are mandatory, research exemptions in your state. Parents need to be researching this stuff or we will all lose the right to chose for our kids.
     

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