In late June, I went to see a dermatologist about hair loss. My hair is still acceptable; it's just reduced in volume and changed texture to be smoother and finer. My part is much more noticeable, and one very visible but tiny part of my scalp right at my front hair line kept driving me crazy. It took me a while to accept that it was really hair thinning, rather than just seeing my gray roots. I think this all happened in the last three or four years. Before that, I had pretty thick hair with fairly course strands and a wavy texture that was actually kind of troublesome to keep from frizzing. Initially, the PA at the dermatologist's office had blood work done. She didn't measure hormones, but looked at other levels. My vitamin D was really low, but she recommended I see my regular doctor about it and my TSH being a tiny bit high, he didn't see cause for concern. Since my actually thyroid levels were in the middle of normal, he felt that if we ever retested right then, my TSH would be normal. I'm taking over the counter D3 and will have that retested in October. The PA at the dermatologist recommended I start minoxidil and told me about spironolactone. Since I was already taking two blood pressure medicines, I talked to my doctor to see about dropping one to take spironolactone instead. My initial dose of spironolactone was only 25 mg, so I don't think I will get any hair loss benefits until I've been on a much higher dose for a while. I have been taking 37.5 mg of metoprolol twice a day and I had been taking a calcium channel blocker as well, but the CC blocker has been discontinued to add the spironolactone. I expressed concerns about metoprolol causing hair loss to both the derm PA and my doctor, and both seemed to think it was unlikely to be contributing the hair loss. I started minoxidil. I don't know the strength because this is a special compounded product with some other active ingredients, one to help with absorption and one to help with scalp irritation. The PA indicated that the concentration of the minoxidil was high enough that one night time application would be all I needed. I would say that my hair loss increased with the use of the minoxidil product and the 25 mg of spironolactone, and that my part looks worse than when I started. I think that the rate at which I was losing hair after starting the drugs has slowed. Since I'm increasing the dose of spironolactone gradually, if it does cause some shedding of its own, I would see some increased loss for a few weeks, I supposes. My plan is to continue both until Christmas and then evaluate my progress. On the follow up about a month after my first visit, the PA did a scalp biopsy and it came back "consistent with androgenetic alopecia." I don't have a copy of it to give the specifics of what the follicles were like exactly, but there was description. I was super disappointed because I hoped that I would have a cause that could be identified and eliminated, but instead, I got a diagnosis that meant that best case, I'd take two drugs to maintain my hair for the rest of my life and that would be an excellent result if they worked. I'm not asking for false hope, but I have some questions that maybe you all could help me with: 1. Does anyone have experience with taking metoprolol for several years and having it change her hair? 2. My hair texture has changed to become smoother and finer in addition to thinner over the last three or four years (about the same about of time I've been taking the metoprolol FWIW). It would seem absolutely amazing to me that I could have completely gone that far into the miniaturization process that all of my follicles have changed in such a short period of time, considering the way that hair growth cycles are theoretically supposed to work. Does anyone know if blood pressure medicines can change hair texture or thickness? Can your hair size and texture change in response to gradually decreasing hormones in your 40s without it being related to Androgenetic Alopecia? 3. As far as I know, no women in either side of my family experienced hair loss until they were considerably older than I am now, like up in her 70s. My dad was pretty bald, though, but his started in his late 20s. Is the genetic component of this just kind of wildly unpredictable? 4. I like some of the effects of taking a beta blocker. I'm a little high strung and I think that the effect of slowing the heart rate moderates my reaction to stress. If my PA and Dr. are correct, and it's not likely that metoprolol is contributing to hair loss, I'd like to keep taking it. But if it's accelerating the hair loss, I want to quit. Any advice on how I can tell the difference? 5. How can you tell what dose of spironolactone you need? I'd like to take the smallest effective dose to preserve my hair. I think it's going to be between 100-200. How much do you have to take to get the anti-androgen effects and protect your follicle? Is there a blood test that can done to tell? Thank you for reading this. I know it was long, but this is the only place that I can expect people to have any idea what I'm asking and to be interested and concerned about hair loss.