After a year of ophiasis-diffuse Alopecia Areata, I have decided to try a Prednisone pulse and Methotrexate treatment. I have about 50 percent hair loss now and what is left is very, very thin. I lost both eyebrows, but did get some brows back with injections. Body hair is also getting sparse. I am posting my regimen for anyone who might be interested in this treatment. I am well aware it is not a cure, but am hoping to calm dowm my immune system if nothing else. These are serious drugs and I recently found out I have osteoporosis, and I really had to fight to get my derm to prescribe it. I am starting on Prednisone at 50mg for 7 days, then tapering to 40, 30, 20, and then 10, all for 7 days. At the same time, I am taking Methotrexate at 20mgs. Once a week with folate every day. I have to take Calcium and vit D and Fosamax for the ostoporosis and get blood work done for liver evaluations. I can continue on the Methotrexate for a long time once I have to stop the Prednisone and can continue with scalp injections if I want to help maintain any growth. I have done 1 week so far and have had no side effects, not even insomnia and have lost 5 pounds, although I was always very thin. It is too early to see results, but will update if anyone is interested. Everyone is different in the way they react to any Alopecia Areata treatment, but I tried to find out as much as I could before deciding to try this so I had some idea of what to expect. I know many people feel that jeopardizing your health is not worth it and I totally respect that, but I am just not ready yet to raise the white flag.