I started 50 mg 1 X day in mid August. At the same time my integrative nurse practitioner changed my progesterone dose and the kind I take. My hair has started growing again and looks better (I think.) But my periods have been irregular since the end of August. I called and asked the pharmacist if the Spironolactone would do this and she seem to think it would be more likely the change in progesterone. I am now going to a new integrative doctor that I really like. I guess I will have to call him and see what he thinks. He has me on some new things for my adrenals so who knows. Maybe that is making a difference in my hair. That's what I get for changing and adding new things to my regime. I am afraid the new doctor. is going to say quit the Spironolactone and then my hair stops growing and starts falling out again. Anyone have irregular periods on Spironolactone?